World's largest release of comprehensive human cancer genome data helps speed discoveries

World's largest release of comprehensive human cancer genome data helps speed discoveries

Tuesday, May 29, 2012

To speed progress against cancer and other diseases, the St. Jude Children's Research Hospital ? Washington University Pediatric Cancer Genome Project today announced the largest-ever release of comprehensive human cancer genome data for free access by the global scientific community. The amount of information released more than doubles the volume of high-coverage, whole genome data currently available from all human genome sources combined. This information is valuable not just to cancer researchers, but also to scientists studying almost any disease.

The release of this data was announced as a part of a perspective published in Nature Genetics online May 29.

The 520 genome sequences released today are matched sets of normal and tumor tissue samples from 260 pediatric cancer patients. The Pediatric Cancer Genome Project is expected to sequence more than 1,200 genomes by year's end. Each sample is sequenced at a quality control level known as 30-fold coverage, ensuring maximum accuracy. St. Jude researchers are analyzing the genomic sequences to determine the differences between each child's normal and cancerous cells to pinpoint the causes of more than a half-dozen of the most deadly childhood cancers, an effort which has already produced a number of key discoveries reported in top scientific journals.

"This effort has generated more discoveries than we thought possible," said James Downing, M.D., St. Jude scientific director who leads the project at St. Jude. "We want to make this information available to the broader scientific community so that, collectively, we can explore new treatment options for these children. By sharing the information even before we analyze it ourselves, we're hoping that other researchers can use this rich resource for insights into many other types of diseases in children and adults."

Launched in early 2010, the Pediatric Cancer Genome Project is the world's largest effort and investment to date to understand the genetic origins of childhood cancers. The three-year project will cost an estimated $65 million. St. Jude is covering $55 million of the cost, including a $20 million commitment from Kay Jewelers, a long-standing partner of St. Jude. This is the first major privately funded human genome sequencing project to share its data as soon as it becomes available. To date, this type of open access has largely been restricted to government-funded efforts. Non-government efforts are typically treated as proprietary.

"Setting this precedent reflects a commitment to freely sharing information that has been a hallmark of St. Jude since we opened our doors 50 years ago," said Dr. William Evans, St. Jude director and CEO. "The Pediatric Cancer Genome Project is a one-of-a-kind effort, so the information has the potential to accelerate disease research worldwide."

Researchers worldwide will be able to access the sequence data via the Web-based European Genome-Phenome Archive, which provides large datasets for free access by researchers on request: www.ebi.ac.uk/ega/organisations/EGAO00000000046.

While most cancer genome initiatives focus only on genes, which make up a small portion of the genome, the Pediatric Cancer Genome Project researchers have taken a different approach. They are sequencing the entire genome ? all the DNA ? in each patient's tumor. This provides a richer, more complete picture of the DNA changes underlying the development and progression of each patient's disease.

"This approach has been more valuable that anyone could have predicted," says Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis. "We have identified unusual, 'cryptic' changes in many patients' cancer cells that we would not have found using other methods. We are pleased to be able to share this data with the research community in hopes that others can build upon our initial discoveries."

The Pediatric Cancer Genome Project has already yielded significant insights into aggressive childhood cancers of the retina, brainstem and blood published in leading international scientific journals. Project researchers working on the eye tumor retinoblastoma discovered clues to the tumor's rapid development that enabled them identify a promising new anti-cancer agent. Investigators studying a deadly childhood leukemia known as early T-precursor acute lymphoblastic leukemia (ETP-ALL) found unexpected genetic alterations that could change diagnosis and treatment for patients with this disease. Efforts to understand the genetic changes underlying a brainstem tumor called diffuse intrinsic pontine glioma (DIPG) found that a startling 78 percent of the tumors carried changes in two genes not previously tied to cancer. Most recently, project researchers identified a gene mutation associated with a chronic and often fatal form of neuroblastoma?a discovery that provides the first clue about the genetic basis of the long-recognized but poorly understood link between treatment outcome and age at diagnosis.

"These findings would not have been possible without the Pediatric Cancer Genome Project," said Downing. He said these results offer new strategies for finding and treating these high-risk cancers. The project has also demonstrated the marked differences between pediatric and adult cancers, underscoring the importance of developing therapies specifically for childhood cancers.

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St. Jude Children's Research Hospital: http://www.stjude.org

Thanks to St. Jude Children's Research Hospital for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Personalized Blood Pressure Therapy May Help Diabetics Your ...

Aggressive efforts to control blood pressure in people with diabetes may be leading to overtreatment with blood pressure drugs in some patients, a new study suggests.

Researchers examined data from nearly 1 million diabetes patients treated at Veterans Affairs health facilities across the United States and found that as many as 82 percent were receiving treatment to keep their blood pressure under control.

However, more than 8 percent of patients were possibly being overtreated to control their blood pressure, and 6 percent were not being treated as aggressively as they could be, the study found.

The findings, published online May 28 in the journal Archives of Internal Medicine, suggest that the current one-size-fits-all method of blood pressure control needs to be reconsidered, the researchers said.

This personalized approach should be possible with the help of electronic health records, which can combine blood pressure, prescription and other health data on patients individual risks such as heart disease or balance problems, the study authors explained in a University of Michigan Health System news release.

Appropriately treating blood pressure in people with diabetes is extremely important, and good blood pressure control should still be the goal to reduce risk of heart attack, stroke and other conditions, first author Dr. Eve Kerr, director of the Center for Clinical Management Research at the VA Ann Arbor Healthcare System and a professor of internal medicine at the University of Michigan Medical School, said in the news release.

But just treating to a blood pressure target in all patients may result in overtreating and harming some patients because their blood pressures actually fall too low, she added. We need to find better ways to measure and incentivize appropriate blood pressure management to make sure that patients who need aggressive treatment are getting it, and to decrease the rate of inappropriate overtreatment.

The American Diabetes Association has more about high blood pressure and diabetes.

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NEW JERSEY ARTS INCUBATOR RELOCATES TO OSKAR ...

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Home / News / NEW JERSEY ARTS INCUBATOR RELOCATES TO OSKAR SCHINDLER PERFOMING ARTS CENTER Arts Incubator to Produce and Present Year Round Programming at OSPAC

West Orange, New Jersey, May 29, 2012 ? The New Jersey Arts Incubator (NJAI) has entered into an agreement with the Township of West Orange to begin presenting year round programming at the Oskar Schindler Performing Arts Center (OSPAC). Founded in 2006, NJAI has served the West Orange community by providing arts programs and events including the successful monthly open mic series Caf? Zed, art gallery exhibits, children?s theater workshops, poetry readings, educational workshops and more.

Under the direction of Executive and Artistic Director of the New Jersey Arts Incubator, Carol Berman, OSPAC will add additional artistic disciplines to the programming and work towards creating an all-weather, year round facility. ?I am really excited to build upon the foundation created at OSPAC to bring new and diverse programming to the facility. Our plans include creating a facility that supports our mission, serves the New Jersey artist community and is a gathering place and events location for the residents of West Orange,? said Carol Berman. ?We will both present and produce theater, music, dance, gallery exhibits, classes, summer camp programs and more.?

?The New Jersey Arts Incubator was created in West Orange to be an arts based economic development tool for the community from the onset, while providing New Jersey artists a place and the tools where they could develop their arts based businesses, create and present the world class art that is indicative of our state. Now, NJAI is poised to fully embrace our core mission with this partnership with the Township of West Orange, at the Oskar Schindler Performing Arts Center,? said NJAI founder and Chairwoman Amy Simon. ?In addition to the OSPAC amphitheater building and grounds, there are five additional acres of open space that abut the property which we hope to help the township utilize for art and environmental use, creating an 8+ acre art park for residents and visitors to enjoy.?

?We are all aware of the value of investing in the arts in our communities, not only as a way to engage our residents but also as a way to bolster the economic realities of our small businesses,? said West Orange Mayor Robert Parisi. ?Creating this partnership at OSPAC with the New Jersey Arts Incubator, one of our established West Orange Arts organizations, is a great opportunity for our community.?

About the New Jersey Arts Incubator
The New Jersey Arts Incubator is an organization dedicated to the economic and creative growth of performing and visual artists, musicians and writers in New Jersey. As the product of that goal, NJAI provides education, programming and revenue raising opportunities, and is both a producing and presenting organization.

The mission of NJAI is to act as a community development and revitalization tool for the Township of West Orange, by utilizing and supporting the region?s arts and organizational communities, providing educational opportunities to all socio-economic and cultural groups, establishing local business partnerships, and by creating a destination in, and economic driver for, the Township.

About the Oscar Schindler Performing Arts Center
Oskar Schindler Performing Arts Center, nestled on a mountain ridge next to Crystal Lake in West Orange, New Jersey, was built in 2000 by developer Larry Pantier to honor the famous rescuer of over a thousand Jews during the holocaust, including his father. Mr. Pantier bequeathed, in perpetuity, the facility and five bucolic acres to the township as an arts and entertainment venue. Under the leadership of the Friends of the Oskar Schindler Performing Arts Center and executive director Ms. Kate Baker; OSPAC has grown to be a first class facility known for its world music and jazz festival performances.

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Blog Archive ? The true significance of the word adult

May 29

How can one classify a true adult? Many people directly attribute age to adulthood. The problem with this methodology becomes evident when you discuss the topic with various people of different cultural backgrounds. Adult may not mean you can operate the raymond mill. If you ask each of them what age they believe constitutes the point at which a person progresses from childhood into adulthood, their answers will always be different. Why? Because every one of the answers are based on subjective opinion. Adulthood is not based age; it?s based strictly on emotional maturity.
So what constitutes emotional maturity, and thus adulthood? Here are 20 defining characteristics of a true adult:
Realizing that maturity is an ongoing process, not a state, and continuously striving for self improvement.
Able to manage personal jealousy and feelings of envy.
Has the ability to listen to and evaluate the viewpoints of others.
Maintains patience and flexibility on a daily basis.
Accepts the fact that you can?t always win, and learns from mistakes instead of whining about the outcome.
Does not overanalyze negative points, but instead looks for the positive points in the subject being analyzed.
Is able to differentiate between rational decision making and emotional impulse.
Understands that no skill or talent can overshadow the act of preparation.
Capable of managing temper and anger.
Keeps other people?s feeling in mind and limits selfishness.
Being able to distinguish between ?needs? and ?wants?
Shows confidence without being overly arrogant.
Handles pressure with self composure.
Takes ownership and responsibility of personal actions.
Manages personal fears.
Able to see the various shades of grey between the extremes of black and white in every situation.
Accepts negative feedback as a tool for self improvement.
Aware of personal insecurities and self-esteem.
Able to separate true love from transitory infatuation.
Understanding that open communication is the key to progression.
Above all, true adults do what they have to do when it is required of them, and they do what they want when they can. They are able to distinguish between the two and manage their time and efforts accordingly.

This entry was posted on Tuesday, May 29th, 2012 at 9:27 pm and is filed under Stuff We Like. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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Online Internet marketing Business enterprise For Beginners | Article ...

Currently, lots of men and women from all more than the world at the moment are contemplating starting a web-based business enterprise. Whether or not you?re a substantial school graduate or possibly a specialist, any individual can start out several kinds of organizations on the web.

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Internet marketing is one from the most well-liked techniques employed by online firms to optimize their web site. This really is by advertising their web-sites so that it?ll acquire rank from major internet search engine, exactly where quite a few world wide web users use to find sites that offer the goods and service they will need.

Internet marketing could sound uncomplicated. It could be tricky for anyone who is a beginner. Hence, here are some tips for making your online marketing strategy a success.

Writing Content articles

Writing and publishing posts is one with the helpful types of promoting your online enterprise inside the net. Whatever you do is write about your online small business and promote your services in the ending of one?s article. Soon after finishing your write-up, current your completed post to internet websites that publishes articles.

Join Forums

Signing up for forums is also one in the finest techniques to marketplace your on line company in the world-wide-web. Be a part of groups that are discussing subjects connected for your on the internet organization. There is a chance that quite a few people today have questions about a particular item and answering them may possibly not only make you appear excellent but men and women who requires a check out the dialogue could possibly get fascinated and quite possibly take a look at your web-site. Just do not neglect to place your title and web-site after each and every post.

Advertise on Other Websites

Advertising and marketing your on the net company on other web sites is also an extremely helpful online marketing method. The draw back is most internet sites that gives marketing in their internet site costs an marketing charge. So make sure you uncover a good internet site to advertise on. A good web page really should have lots of guests to make sure you that lots of people will essentially see your marketing. Also, locate internet sites connected to your on the internet business enterprise. Advertising on the site is commonly inside the kind of banners and text backlinks.
E-mail Checklist

This sort of internet marketing process is really a great method to reach out personally to quite a few world-wide-web users. The only drawback to this process is the fact that most of the well-known e mail service companies including Yahoo! Mail, Google, Gmail and MSN email messages have features which can mark your e mail concept as spam. Most users delete the contents in their spam folder even just before they appear inside.

There are actually on the web firms that present internet-marketing services. For different fees, they?re going to look after the internet marketing for the on-line business. All you may have to do is give them some details about your online small business and specify what sort of internet marketing technique you choose.

They are just several of the approaches to industry your on the net company in the online. There are plenty of types of various online marketing methods.

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Will Smith & Jada Pinkett Smith Discuss Their Marriage

Will Smith and his wife Jada Pinkett Smith know that being both married and famous can be tough, but they've both resolved to always be supportive and present when it counts. 

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Nine amazing outdoor hotel suites

Amangiri offers sweeping views of quiet desert in southern Utah.

By Conde Nast Traveler

Sheets, quilts and pillows may seem strange bedfellows for the open air, but these are cozy sleeping platforms that referee civilization and nature. Here are nine of the most spectacular hotel suites in the world.

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Amangiri Resort
Lake Powell, Canyon Point, Utah

A full moon showcases the mesas against the sky. At night the occasional coyote yips, and at dawn bighorn sheep may troop by. Welcome to Amangiri, the extravagant 600-acre resort near the Navajo Nation in Utah as it cuts in near Page, Arizona. This is one of the best places in the United States for star-gazing: The air is clear and dry, and there's very little ambient light. If you'd like less exposure but a more focused relationship with the starry pitch above, six Amangiri suites have "Sky Terraces" ? three protecting walls with the open sky above and a pool below. With summer nights in the 60s and January nights in the mid-30s or lower, there's appropriate bedding ? from silk and wool throws to plumped down quilts. Cocoa with a shot of brandy? Coffee at 5:30 a.m.? This is Amangiri (435-675-3999; suites, $1,500?$3,500).

Lion Sands Private Game Reserve
Sabi Sand Game Reserve, South Africa

Guy Aubrey Chalkley, who founded Lion Sands in 1933, used to tell his daughter when she slept out on the Chalkley Treehouse, "Never fear the roar of the lion for it is rather when you don't that you need to be aware." Over the past 60 years, this tree house ? built as a photographer's platform ? has been reinforced and adorned with a cozy double bed, a hot-water bottle, dressing gowns and a basin. Guests can have dinner and drinks in the tree or dine at the lodge and head out afterward. Once dropped off ? with mosquito repellent, torches, lanterns and a two-way radio ? they're on their own until morning. Chances are that during the night you will hear a lion roaring to stake his claim. This part of South Africa, bordering Kruger National Park, has a high concentration of noisy predators: Hyenas and jackals engage in chitter chatter. At sunset and sunrise birds chime in. The tree house sits on the edge of an open plain: You may be able to hear the Sabie River, about a mile away. The sun sets and evening emerges; when the moon is full, you might see its light shimmering off the elephants less than 200 feet away across the plain. They are remarkably silent under the spectacular night sky ? the Southern Cross, shooting stars, satellites ? which is all yours, from horizon to horizon (27-11-484-9911; tree house, $254).

Las Ventanas al Para?so
Los Cabos, Mexico

From the terrace of your penthouse high above Las Ventanas al Para?so, at the tip of Mexico's Baja Peninsula, you have a 180-degree view of the Sea of Cort?s, about 150 feet away. The bed is king-size, the breezes and waves are gentle, and the sounds are ambient ? birds at sunset and sunrise. The mountains 40 miles inland are lit and shadowed by the moon. Far-off houses warm the night with the reassuring calm of distant civilization. At around 10 p.m., you might see fireworks in the distance; celebrations are easy to come by down here. But the later it gets, the more silent the night becomes. As the penumbra subsumes the whites and blues and greens, the fragrance distilled by the heat of the day rises?the smells of sand and earth, the ozone released by breaking waves, the scent of jasmine. Here's your essential equipment: All suites have telescopes and guides to the constellations (52-624-144-2800; penthouse suites, $1,600?$3,780).

Blue Mountains Private Safaris
Blue Mountains National Park, Australia

"You know the song? 'Once a jolly swagman?'?" asks Mark Tickner, who takes guests into the bush for Blue Mountains Private Safaris. A swagman, he says, is a nomad who sleeps in a swag. But here, the swags are padded, lined with fine cotton, and laid out on decks by the Wollondilly River, 75 miles southwest of Sydney, where the eucalyptus forests yield their oily vapor to the sun, leaving a scent and a blue haze that gives the mountains their name. After days spent hiking the sandstone escarpment and deep gullies, viewing platypuses, kangaroos, wombats and echidnas, slip into your swag. Dingoes howl, parrots and eagles screech, rapids roar. At dawn, the kookaburra laughs (yes, sitting in the old gum tree) and grazing kangaroos thump around in the bush (61-2-9571-6399; doubles, $1,317).

L'Albereta
Erbusco, Lombardy, Italy

Industrialist Vittorio Moretti has a theory about houses, that each should have a pensatoio at the top ? a place surrounded by windows where a person can pause, contemplate nature and refresh. So L'Albereta, his family's Relais & Ch?teaux hotel in the hills of Franciacorta, between Brescia and Bergamo, has the Cabriolet Suite. Atop a tower facing Lake Iseo, you are in the clutches of Northern Italian luxury ? sitting on satin, grosgrain, damask; surrounded by vineyards; fed by the great Milanese chef Gualtiero Marchesi. Feeling romantic? Press a button and the roof above the bed opens to the heavens. During the annual Perseid meteor shower (known here as the tears of San Lorenzo), the suite is particularly sought after: Legend has it that for every falling star, a wish will be granted. But the sky is beautiful anytime, and the nights can be full of the perfume of wild roses, jasmine and gardenias (39-030-776-0550; Cabriolet Suite, $617).

Loisaba Wilderness Lodge
Nanyuki, Kenya

Loisaba, on Kenya's Laikipia Plateau, has spurred 10 marriage proposals. "It's all about the beds," says owner Tom Silvester. "They are ridiculously comfortable." You're just off the equator, amid acacia woodland and savanna, not far from the Rift Valley, the birthplace of modern man. There are two Star Bed camps: Kiboko, by a huge water hole that attracts wildlife, and Koija, on the Ewaso Nyiro River (you can hike from one to the other). Inspired by a Mukokoteni handcart and built on an old Land Rover axle, each bed is on a large platform set about 10 feet off the ground and 100 feet apart, ensuring privacy. In the evening, the Masai and Samburu who run the camps wheel them out from under a palm-thatch roof. The air is clear 300 days a year, granting full access to the wonder of African skies (254-20-600-3090; doubles, $1,190).

Adr?re Amellal Desert Ecolodge
Siwa Oasis, Egypt

Adr?re Amellal, built of mud and salt crystals, sits at the foot of a flat-topped white mountain considered holy by the local people. The lodge uses no power except for the generator that runs the kitchen. Outdoor beds are set up on the roof or out in the desert, south of the Siwa Oasis. In an immense "ballroom" (a bowl between tall dunes), dinner is served at magnificent tables set with crystal and argenterie. Later, Siwan staff in turbans and tunics escort you into the desert. They don't use flashlights; you walk up a dune in the pitch black. On the other side are real beds made of palm reeds, with proper quilts and pillows and Egyptian cotton sheets. But if you fall asleep, you'll miss the magic of absolute silence (20-2-2736-7879; Desert Rooms, $800; open Sept.?July).

Killa Bhawan
Jaisalmer, Rajasthan

In Jaisalmer, a living fortress high above the surrounding small city of the same name, a Killa Bhawan guest might follow local custom and sleep out on the roof, in a well-made colonial bed. Jaisalmer's magic is magnified by its isolation in the middle of the Indian desert. Known as the Golden City, it was built in the twelfth century of yellow limestone marble and is famous for its palace, which you can see from the terrace, as well as its exquisite havelis (mansions) and seven Jain temples. Night brings a little wind, a clear desert sky, and the sounds of the city bedding down. Three thousand people live in the fort; in the temples, the worshippers sing and drum, then motorbikes head home, and by 10 p.m. all becomes quiet. Life begins again around 6 a.m. with the bells of the temples and first prayers (91-2992-251204; doubles, $120?$200).

Ol Donyo Wuas
Kenya

At Ol Donyo Wuas, there's a permanent bower on the roof deck above every suite that can be done up with fresh soft cotton linens, blankets, and hot water bottles. By moonlight, the savanna below is visible, as is Mount Kilimanjaro in the distance. The lodge, which sits on a ridge 50 feet above the plains, is surrounded by three water holes, and at night you can hear elephants sloshing around. When the moon is new, the sky is black and the heavens are so close that satellites and shooting stars seem to careen overhead like fireflies (254-20-600-0457; doubles, $1,220?$1,620).

More from Conde Nast Traveler

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Pre-owned Vehicle Video Reviews Launched by WheelsTV and - Toys

Acton, MA (PRWEB) January 21, 2009

WheelsTV today announced the launch of POV Reviews , comprehensive video reviews of late model pre-owned vehicles.

This suite of videos incorporates JDPower.com?s Power Circle Ratings, based on feedback from verified vehicle owners derived from J.D. Power and Associates annual syndicated studies. These ratings are brought to life with full-motion, broadcast quality video from WheelsTV.

?With POV Reviews, consumers can now do five hours of research in just five minutes, getting a comprehensive review of every make and model within a generation of each vehicle. This is a new and effective tool to assist dealers in selling pre-owned and certified pre-owned vehicles,? states Lehel Reeves, president of WheelsTV.

POV Reviews makes shopping for a pre-owned vehicle quick and easy, gathering consumer feedback from millions of motorists, conducting independent research and encapsulating findings into brief video programs. The WheelsTV Review Board does all the work for the car shopper.

JDPower.com?s Power Circle Ratings are presented in an easy to understand video format that demonstrates important vehicle attributes from fuel economy to reliability, safety and comfort. Data is collated and encapsulated into concise narrative and clear, easy to read data screens, which cover multiple vehicle years and demonstrate trends.

?POV Reviews present the JDPower.com Power Circle Ratings in a way that?s useful and meaningful to consumers,? said Peter Marlow, vice president of corporate communications and consumer development at J.D. Power and Associates. ?We?re pleased to work with WheelsTV to present information in a way that gives consumers the information they want, when they want it, in a rich media format.?

In addition to JDPower.com?s Power Circle Ratings, safety and crash test data is presented in association with the Insurance Institute for Highway Safety including actual crash test video documentation and ratings. WheelsTV?s patent pending process then combines the data screens, action footage of each vehicle, voice-over narration, music and effects to create a valuable tool for both consumers buying cars and dealers selling cars.

Pre-owned vehicles out-sell new vehicles by three to one. With POV Reviews consumers are given the ability to quickly and easily research, compare and choose the best pre-owned vehicles for them, saving time and money. This vehicle shopping tool is the first video product to serve the world?s largest consumer market at a time when more motorists are turning to pre-owned vehicles to fill their transportation needs.

For more information, please contact Theresa Carlo at WheelsTV: TCarlo(at)WheelsTV(dot)net, 978-264-4333.

About WheelsTV

Headquartered in Acton, Massachusetts, Automotive Networks Corporation, d/b/a WheelsTV (http://www.wheelstvtestdrives.com), creates and distributes exclusive original content domestically and worldwide on the Internet, broadband, VOD and 3G mobile platforms. WheelsTV?s patent-pending products include Top 200 Test Drives and1:00 on One Vehicle Profiles, providing the optimal consumer experience to its distribution partners including, J.D. Power, AutoTrader, MSN, AOL, Amazon, AutoNation, Yahoo, Vehix, Chrome Systems, Reynolds and Reynolds, Kia, Azuki Systems mobile, Comcast On Demand, Charter Cable, Cablevision, Quebecor and OEM franchise dealers throughout North America.

About J.D. Power and Associates

Headquartered in Westlake Village, Calif., J.D. Power and Associates is a global marketing information services firm operating in key business sectors including market research, forecasting, performance improvement, training and customer satisfaction. The firm?s quality and satisfaction measurements are based on responses from millions of consumers annually. For more information on boat ratings, car reviews and ratings, car insurance, health insurance, cell phone ratings, and more, please visit JDPower.com. J.D. Power and Associates is a business unit of The McGraw-Hill Companies.

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Worthington Civic Center Upgrades Completed

Worthington-West Franklin Joint Parks and Recreation Authority Chairman Bill Hodak walks across a new gymansium floor in the Worthington Civic Center last week. The floor was replaced thanks to community donations and a match donation from Rosebud Mining.

by Jonathan Weaver

Donors who gave toward two Worthington Civic Center upgrades last year can now see the results.

The civic center?s gymnasium floor has been repaired and the parking lot repaved after a community fundraiser orchestrated by the Worthington-West Franklin Joint Parks and Recreation Authority netted $40,000. Rosebud Mining agreed to match $20,000 if the community donated the other half, which the organization raised in eight months.

The final contribution was received in December 2011.

With the library next door and a little league field close-by, patrons will now be able to park without risking vehicle damage. Authority Chairman Bill Hodak was elated with the paving work performed by White?s Paving of Worthington, of which included extra sealant

?We were really impressed, really surprised that they did this much,? Hodak said.

Owner Fred White said the company donated two loads of asphalt and will line-stripe it this summer, worth at least $4,500. His 17-member crew took an extra day in May to do the repairs.

?We donated that to do a better job,? White said. ?We were just supposed to do base repair and fix some of the worst spots. Well, we fixed them, scratch-coated and leveled it out a bit more with paving so we could tar-and-chip it so it would be a lot smoother.?

The lot was tar-and-chipped last weekend.

Wood Floor Technicians performed the indoor repairs to the gymnasium floor, something Hodak said was a long-time coming.

?It has been a long time ? no one knows when it was done last,? Hodak said.

Armstrong Community Theatre Director Paul Wright was in the refurbished auditorium for the first time before April?s dinner theatre production of ?Murder at Caf? Noir and was also impressed by the work performed.

?The floor looks wonderful ? you walk into this room and don?t even know the trim is missing because your eyes are on the floor,? Wright said. ?Those people that have been in this room before and seen the floor will be shocked when they come in here.?

Young?s Flooring of Ford City installed new carpeting along the walls, and the Worthington Lions Club ? led by John Good ? volunteered to paint the remainder.

Hodak said a basketball hoop will also be installed in the gymnasium for recreational sports.

The parking lot was also repaved thanks to White's Paving in Worthington. Initially, only troublesome spots in the lot were to be fixed, but the company donated labor and material to fix up the rest.

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DC SHOES: GYMKHANA FOUR-BONUS EDIT

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Net Zero Is Bliss At Maharishi University In Iowa

Maharishi Mahesh Yogi is best known for having brought Transcendental Meditation to the West, but he also founded the Maharishi University of Management (MUM) in Fairfield, Iowa (yes). Now, the university?s Schwartz-Guich Sustainable Living Center will give students an opportunity to experience sustainable living firsthand.

Incorporating principles of Bau Biology (a German system that focuses on creating a healthy indoor environment), as well as Maharishi Vedic Architecture (an Indian system of architecture focused on the precise orientation, proportions and placement of rooms), the MUM Sustainable Living Center was designed to surpass LEED Platinum qualification while complying with most of the criteria of the Cascadia Living Building Challenge. It will operate entirely off the grid.

image via Maharishi University of Management

The building is one of the few in the country to qualify as net zero, and one of even fewer that can claim the banner of grid positive (i.e., it produces more energy than it consumes) via its solar power system.?A rainwater catchment system and on-site natural waste-water treatment likewise take the building off (sewer) grid with respect to water and waste treatment.

Additional green features include natural daylighting in evey room; natural, breathable earth block walls (which were made by the program?s students), purified rainwater for both potable and non-potable water functions; and an on-site water purification and recycling system consisting of plants, algae, and bacteria.

The building is named after MUM trustee Eric Schwartz and his wife, Mary Sue, and MUM alumnus Dr. Steve Guich. More about the building is available online.

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Cystic nodular acne treatment - Health and Fitness

Eight glasses of water a day can keep acne away.? says Jennifer Thoden, a respected acne expert. With that distinction made, let me state unequivocally that achieving permanent clear skin is never really ? easy-. Now and that you? re riled up and ready to get rid of these pesky invaders of your otherwise gorgeous skin, it? s time to do something about acne. Your skin can be more oily and lead to more blocked pores and not just on the face. Try dipping some cystic nodular acne treatment cotton wool into the juice of freshly squeezed oranges and lemons. lumps formed on the body. That is understandable. Creams are supposed to unblock your pores thus halting bacteria breeding on your skin. Your dandruff may be falling on your back, and with your oily skin: Those dandruff particles may seep into the pores of your back, causing infections which lead to pimples and other flare- ups. The best acne treatments may include such things as:
- Hormonal treatments that contain acne specific amounts of steroids that will attack the acne on your face. Please don? t become disheartened if you? ve used other products in the past that have not worked. Given that pimples may appear at any given time, knowing how to deal with them on ones own is a plus. Lemon juice works because the before acid attacks nodular the bad bacteria that cause acne to form. For many kids, acne lesions are physically and emotionally scarring. Click read more on acne treatment, natural ways treatment to get acne rid of acne. Use it like a face wash, making treatments sure to gently rub it on your face for 5 minutes. Olive Oil Clearing acne scars is an easy job with the help of olive oil. After washing carefully, you dab your face dry with a towel. This could in fact be the case when it comes to adults going through acne for the first time. Apply toothpaste on the pimples at night before bedtime and wash in the morning. Acne medicine is continually being developed and improved for acne treatment. An excellent anti acne treatment method is Clear Epidermis MAX. 6. Things such as refined and processed foods can cystic nodular acne treatment be a huge source of the problem. Tea Tree Oil Commonly used and seen in households, tea tree oil can be purchased in most supermarkets and groceries. Therefore, treatments that help to control the level of hormones in the body are particularly promising as an acne remedy. Topical treatments such as BioSkincare, Kelo- cote, Mederma and Retin- A are just some of the remedies that can be scar easily purchased and used. Though not every single one of the existing products are helpful, quite cystic a few have been acne scar treatments before and after after established based on their active agents. Acne prone skin can be quite an ordeal to live with.

Related Post Cystic nodular acne treatment

The more these people drank milk the higher the risk became. The bacteria population on the skin is bathed in blue light in a Programs that suggest mega doses of up to 10 grams or more of acne facial B5 each day may be unnecessary. To be honest, It is believed that approximately 25% of adults can experience some form of adult acne at some stage and this doesnt mean that it You can change the dosage of the diluted vinegar to a stronger one if you dont have sensitive skin. They may lose out for Listed here are some natural instead of so normal acne treatments which are proven being productive. Also works on other acne parts of your

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How to Get the Best Performance from Team Members

Whether you?re into finance and accounting services or business support services placing a group of experienced employees together does not guarantee the success of a team. Each member must perform at a high-enough level to ensure that his contribution is an integral part of completing the project. It is the job of the human resource services to get the best performance from team members, work to help maintain momentum until all required tasks are completed.

Individual performance and getting your team to perform are two totally different entities. Indeed, they represent a total shift in paradigm. When you focus on your entire team's performance, your own achievement includes the sum total of the whole team's achievement, and an individual failure can also pull your team performance down.

Below are a few tips on how this can be achieved

1. Conduct a meeting with your team as soon as it forms and explain the mission of the company and why your department or team is important to realizing the goals. Tell the members why they were chosen to fulfill the duties of the project.

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2. Include your team in planning the activities to meet deadlines. Allow each member to determine their duties that lead to the end result. Write down performance plans and reassess regularly to ensure compliance

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3. Encourage employees who do not perform at a high level to take responsibility for their work and help keep the team moving forward. Let the laggard members know that their tasks are important and that other workers rely on them. Remind them about the characteristics they possess that led you to choose them for the team.

?

4. Brainstorm with your team to discover more efficient avenues for task completion. This exercise also shows that you respect your team members' ideas and will listen when approached about new solutions to output delays.

?

5. Allow team members to resolve conflict among themselves, with you as a guide. Ensure that each one respects the other person's idea and position, but make it clear that they must do what's best for the group and the company. Teaching your staff how to place their personal conflicts aside to advance the goals of the team helps them learn how to avoid behavior that slows down progress so they can perform at their best together.

?

6. Reward employees for meeting interim deadlines and completing portions of the larger project. A pizza lunch in the workplace or a half-day off with pay serves to refresh and motivate the team. If your budget allows, organize a morale booster that includes a day of activities and bonding away from the office to encourage your team members to perform efficiently as a team.

Team leaders or supervisors have the task of motivating members to work toward a common goal and maintain positive outlooks about the project and the company. If deadlines are usually short, requiring high energy levels from the team, your staff risks burning out. A good, motivated team is an asset to the company. Maintaining and encouraging healthy interpersonal relations among the employees goes a long way in creating healthy bonds and avoiding unnecessary office politics.

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bwin lan?a a primeira aplica??o de Poker real money para iPhone

(Comunicado de imprensa) O Texas Hold?em em cash games j? est? dispon?vel na App Store

Viena, 26 de Abril de 2011 ? a bwin, empresa l?der de entretenimento online, lan?ou a primeira aplica??o de poker real money para o iPhone. A aplica??o j? pode ser encontrada na App Store no Reino Unido e na ?ustria, estando presente num maior n?mero de pa?ses nos pr?ximos tempos. ?Gra?as a esta aplica??o desenvolvida pela bwin para o iPhone, os nossos clientes podem, pela primeira vez, mostrar o que valem na maior rede de poker do mundo atrav?s do famoso iPhone?, explica Berthold Kao, respons?vel pela gest?o do produto RNG & Mobile na bwin.

A aplica??o bwin poker iPhone oferece um novo leque de possibilidades aos amantes do maior jogo de cartas. A combina??o do jogo mais popular de todos, o Texas Hold?em e uma interface de f?cil uso e registo, permitem trazer toda a emo??o e divers?o para o mundo dos smartphones. A navega??o ? facilitada por um design eficaz da aplica??o, permitindo uma imagem clara e n?tida do jogo. ? exibida automaticamente a melhor m?o de um jogador, assim como com um toque ? exibido o hist?rico da sess?o em jogo. ?Com a aplica??o de poker do iPhone, continuamos a aumentar a nossa lideran?a no mundo do entretenimento m?vel. Em conjunto com a aplica??o bwin Casino Live para o iPhone, podemos oferecer aos nossos clientes um conjunto de aplica??es completo.?, afirma Kao.

Sobre a bwin
O grupo bwin tem mais de 20 milh?es de clientes registados em mais de 25 mercados de topo. Atrav?s de v?rias plataformas, o grupo oferece apostas desportivas, poker, casino, soft e skill games, bem como streaming de a?dio e v?deo dos grandes eventos desportivos, tais como as Ligas Alem? e Espanhola de futebol. A holding bwin Interactive Entertainment AG est? cotada na Austrian Trading Index da bolsa de Viena (c?digo ID BWIN, c?digo Reuters BWIN.VI), e em paralelo com a companhia m?e, fornece servi?os como o desenvolvimento de software, marketing, comunica??es, recursos humanos e finan?as ?s suas subsidi?rias e companhias associadas. O neg?cio operacional do grupo bwin ? realizado pelas companhias subsidi?rias e associadas na base de licen?as (exemplo: Alemanha, It?lia e Gibraltar). Os detalhes completos acerca da companhia est?o dispon?veis no website corporativo www.bwin.org

Matthias Winkler
Chief Communications Officer
bwin Interactive Entertainment AG
B?rsegasse 11, 1010 Vienna, Austria
Tel.: +43 (0)50 858-20067
E-Mail: press@bwin.org
www.bwin.org

Website: http://www.bwin.com

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Venture Capital: Raising Seed Money | Finance World

The doors to venture capital have finally begun to swing open once again. Many venture capitalists were burned in the global recession. Since 2008, the marketplace has changed quite a bit. It is imperative that entrepreneurs understand their options, the demands they will face and the intent of today?s venture capitalist.

Venture capital comes in different forms and at different costs. Before running off to grab the necessary millions to launch the next Apple or IBM, the entrepreneur must fashion an organized plan of attack. Failure to be thorough and professional in the approach to raising venture capital has left many good ideas on the sidelines, mired in an endless pursuit of funding.

As the company prepares to launch its strategy and build a management team, conventional forms of financing are nearly impossible to obtain. The entrepreneur has five basic options in pursuing venture capital and each option comes with different specifications.

? Commercial Banks ? Entrepreneurs with an existing business, a solid balance sheet and several years of verified profit and loss statements and with a deposit relationship with the lender can apply to a commercial bank for capital. The entrepreneur is usually asked to guarantee the loan with individual assets as collateral. Commercial banks rarely participate in launching a new business and the amount of the entrepreneur?s loan will be a percentage of the entrepreneur?s collateral. The new operation will also need to pay interest, which money could be better used to develop the business. When working with today?s commercial lenders, a high degree of transparency is needed. In a commercial loan, the borrower assumes all the risk.

? Investment Banking Firms ? Investment bankers are also called Vulture Capitalists. Often investment bankers only work in specific industries. If the entrepreneur needs funds for expansion of a working business in one of those industries, the investment banker may consider an application for funding.

The investment banker looks for businesses with solid earnings in an industry with growth potential and a management team they like. Already with exposure in an industry, investment bankers can be extremely beneficial for a growing operation.

When applying to investment bankers, the entrepreneur will need fairly precise projections and, of course, accurate financial records. Investment bankers are primarily interested in existing operations that seek a business partner and the vulture must always see a viable exit strategy.

? Venture Capital Groups ? Venture Capital Groups are high wealth investors who have determined to take certain risks. These groups are looking for the next great product, service and miracle concept. The entrepreneur with a new concept will be required to post equity in the new company as collateral, and it could be a significant amount of equity.

The entrepreneur will be forced to give up equity but will gain the funds needed to launch and a partner with proven moneymaking success. Venture Capitalists usually have specialist for each step of the company?s growth, beginning with the Early Stage and advancing to the exciting Start-up Stage.

When approaching a venture capitalist, the entrepreneur must be prepared. You may have 20 minutes to make a compelling first impression. Know your facts, have supporting projections, present your management team?s credentials and explain why there will be demand for your product.

? Angels and Sophisticated Private Investors ? Angels and private investors are out there. Sometimes they are under the same roof. These participants may offer enough funding for the early stage or for expansion, but they are rarely in for the long haul. Angels and investors may require a loan structure or may want equity. Be careful because doing business with friends has destroyed many a friendship.

? Wholesale Investor Magazine and Website ? Wholesale Investor Magazine and Website was created to assist entrepreneurs needing venture capital and to provide a resource for venture capitalists.

Entrepreneurs can post information, projections, concepts and charts about their venture in a private downloadable Information Memorandum format. Investors can download all information posted by the business and will be provided contact information to discuss the investment opportunity with the opportunity.

---

About the Author: The doors to venture capital have finally begun to swing open once again. Many venture capitalists were burned in the global recession. Since 2008, the marketplace has changed quite a bit. It is imperative that entrepreneurs understand their options, the demands they will face and the intent of today?s venture capitalist.

Venture capital comes in different forms and at different costs. Before running off to grab the necessary millions to launch the next Apple or IBM, the entrepreneur must fashion an organized plan of attack. Failure to be thorough and professional in the approach to raising venture capital has left many good ideas on the sidelines, mired in an endless pursuit of funding.

As the company prepares to launch its strategy and build a management team, conventional forms of financing are nearly impossible to obtain. The entrepreneur has five basic options in pursuing venture capital and each option comes with different specifications.

? Commercial Banks ? Entrepreneurs with an existing business, a solid balance sheet and several years of verified profit and loss statements and with a deposit relationship with the lender can apply to a commercial bank for capital. The entrepreneur is usually asked to guarantee the loan with individual assets as collateral. Commercial banks rarely participate in launching a new business and the amount of the entrepreneur?s loan will be a percentage of the entrepreneur?s collateral. The new operation will also need to pay interest, which money could be better used to develop the business. When working with today?s commercial lenders, a high degree of transparency is needed. In a commercial loan, the borrower assumes all the risk.

? Investment Banking Firms ? Investment bankers are also called Vulture Capitalists. Often investment bankers only work in specific industries. If the entrepreneur needs funds for expansion of a working business in one of those industries, the investment banker may consider an application for funding.

The investment banker looks for businesses with solid earnings in an industry with growth potential and a management team they like. Already with exposure in an industry, investment bankers can be extremely beneficial for a growing operation.

When applying to investment bankers, the entrepreneur will need fairly precise projections and, of course, accurate financial records. Investment bankers are primarily interested in existing operations that seek a business partner and the vulture must always see a viable exit strategy.

? Venture Capital Groups ? Venture Capital Groups are high wealth investors who have determined to take certain risks. These groups are looking for the next great product, service and miracle concept. The entrepreneur with a new concept will be required to post equity in the new company as collateral, and it could be a significant amount of equity.

The entrepreneur will be forced to give up equity but will gain the funds needed to launch and a partner with proven moneymaking success. Venture Capitalists usually have specialist for each step of the company?s growth, beginning with the Early Stage and advancing to the exciting Start-up Stage.

When approaching a venture capitalist, the entrepreneur must be prepared. You may have 20 minutes to make a compelling first impression. Know your facts, have supporting projections, present your management team?s credentials and explain why there will be demand for your product.

? Angels and Sophisticated Private Investors ? Angels and private investors are out there. Sometimes they are under the same roof. These participants may offer enough funding for the early stage or for expansion, but they are rarely in for the long haul. Angels and investors may require a loan structure or may want equity. Be careful because doing business with friends has destroyed many a friendship.

? Wholesale Investor Magazine and Website ? Wholesale Investor Magazine and Website was created to assist entrepreneurs needing venture capital and to provide a resource for venture capitalists.

Entrepreneurs can post information, projections, concepts and charts about their venture in a private downloadable Information Memorandum format. Investors can download all information posted by the business and will be provided contact information to discuss the investment opportunity with the opportunity.

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India seeks stronger Myanmar ties as PM visits

SITTWE, Myanmar (Reuters) - In northwest Myanmar, where the Kaladan River flows out into the Bay of Bengal, the two giant arms of a half-built wharf enfold the estuarine mud with steel and concrete.

Their embrace is fraternal - Myanmar's giant neighbor India is funding the new port in Sittwe, the capital of Rakhine State - but also strategic.

The port is part of a $214-million river and road network that will carve a trade route into India's landlocked northeast and underscore New Delhi's determination to capitalize on Myanmar's growing importance at Asia's crossroads.

Manmohan Singh will seek to bolster ties this week during the first visit by an Indian prime minister to Myanmar in 25 years. His official agenda includes road, rail, waterways and air links, says India's foreign ministry.

Unofficially, he must also overcome a history of bad blood with Myanmar, where Indian investments are already dwarfed by regional rival China.

The visit follows a year of dramatic reforms in which Myanmar has pulled back from China's powerful economic and political orbit and won a suspension of U.S. and European sanctions.

President Thein Sein's government has held peace talks with ethnic minority rebels, relaxed strict media censorship, allowed trade unions and protests and held a by-election dominated by Nobel Peace Prize laureate Aung San Suu Kyi's opposition party.

As Myanmar emerges from decades of isolation, trade between the countries is already swelling. Myanmar's government expects two-way trade with India to nearly double in two years to $2 billion, from $1.4 billion in the year to March 30, a figure that was nearly 30 percent higher from the previous year, according to Myanmar's Ministry of Commerce.

India should be a natural partner, with ties stretching back to the ancient Buddhist emperor Ashoka and, more recently, a shared experience of British colonialism and World War Two.

But its business interests in the former Burma have been "few and far between" since the mass expulsion of Indian merchants after the military seized power in 1962, says Thant Myint-U, author of "Where China Meets India: Burma and the New Crossroads of Asia".

"Many in India remember all too well that this was the country that nationalized Indian businesses and expelled hundreds of thousands of ethnic Indians with literally nothing more than the shirts on their backs," he said.

One hopeful symbol of improved ties is Sittwe.

The two countries formally agreed on the so-called Kaladan Multimodal Transit Transport Project in April 2008, just seven months after Myanmar's military junta crushed nationwide pro-democracy protests led by Buddhist monks.

Work began on Sittwe port in September 2010, shortly before the former military junta held a rigged election that brought to power a quasi-civilian but surprisingly reformist government.

Indian conglomerate Essar Group is building the port on 70,000 square meters (753,000 sq ft) of landfill in Sittwe's centre. It should be ready in two years, says Myanmar's Commerce Ministry, accommodating ships from the Indian city of Kolkata, a 539-km (334 mile) voyage away across the Bay of Bengal, and handling up to 500,000 tonnes a year.

From Sittwe, ships will sail up the Kaladan River to the town of Paletwa, where Essar will build a second, smaller port. A 122-km (76-mile) highway will connect Paletwa to the Indian state of Mizoram. The two ports and dredge work will cost $74 million. The highway will cost $140 million.

STRATEGIC SIGNIFICANCE

India is already Myanmar's third-biggest export market after Thailand and China. But Thant Myint-U plays down Myanmar's economic importance to India. "Myanmar is extremely important for India's northeast, but because the northeast itself rarely gets Delhi's attention, that in itself doesn't count for much."

However, New Delhi is acutely aware of Myanmar's strategic significance "because of China's increasing economic presence and anxiety about a possible future Chinese presence on the Bay of Bengal", he says.

Not far south of Sittwe, Chinese money is funding a bigger port and special economic zone in Kyaukphyu, a coastal town where Myanmar-China pipelines reach the Bay of Bengal, creating a passage from western China to South and Southeast Asia and allowing shipments of fuel and natural resources to avoid the Malacca Strait.

An Essar company official said "communication problems" had been a headache during the project, with Myanmar officials slow to provide information and language issues also a hurdle. The company, however, would consider further projects in the country, given they had already worked there.

"Business is all about relationships, and we have been meeting the right people," the official said.

A delegation of Indian business officials will join the prime minister on his visit, said an Indian Foreign Ministry official, adding that India was looking at setting up a special economic zone.

Myanmar opposition leader Aung San Suu Kyi was once lionised by New Delhi, which gave her the prestigious Jawaharlal Nehru Award in 1993 and Myanmar's dictatorship the cold shoulder.

But with growing investment in Myanmar by regional rival China, the world's biggest democracy has forged closer ties, inviting former dictator Senior General Than Shwe on an official state visit to India in 2004.

Three years later, after he presided over a violent crackdown on pro-democracy protests led by Buddhist monks, India was widely criticized for its muted response amid international outrage.

"Manmohan Singh has to do more than offer ports, bridges and roads, as the Chinese do," says Thant Myint-U. "Instead, he has to ... delve deeply into the very long history of cultural ties between the two countries and come up with a new vision for Indo-Burmese relations.

"The problem is that no one in Burma thinks of India when they think of the future."

Still, Myanmar expects to benefit from the Sittwe project, partly from jobs. Essar employs 600 local people on the Sittwe site, although it brought in most of its skilled workers and specialist construction equipment from India.

"This project is good for the northeast part of India and for Myanmar," Myanmar Industry Minister Soe Thein said in an interview with Reuters in the capital, Naypyitaw. "We can't do it ourselves due to the lack of budget and problems in our financial sector."

(Additional reporting by Satarupa Bhattacharjya, Anurag Kotoky and Frank Jack Daniel in New Delhi and Jason Szep in Naypyitaw; Editing by Robert Birsel)

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The landfill nudge at the University of Pennsylvania

Decision makers do not make choices in a vacuum. They make them in an environment where many features, noticed and unnoticed, can influence their decisions. The person who creates that environment is, in our terminology, a choice architect. The goal of Nudge is to show how choice architecture can be used to help nudge people to make better choices (as judged by themselves) without forcing certain outcomes upon anyone, a philosophy we call libertarian paternalism. The tools highlighted are: defaults, expecting error, understanding mappings, giving feedback, structuring complex choices, and creating incentives.

For a user-friendly introduction to choice architecture, check out this paper.

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The Radical Transformation of Barack Obama (Powerlineblog)

Share With Friends: | | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

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[Twitter] My presentation will be with c#, redis, http://t.co/ah1aifKc mvc, mono, ubuntu and a mac. No windows, no visual studio :D #dddsw

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Classified Internet Advertising (Ezine Ready)

Posted by: Abhay on May 25, 2012 Under: Online promotion |

Online advertisements as well as zero cost local classified listings are usually posted within the magazines as well as other seen elements method again prohibited, nonetheless these times it is hence labeled ? outdated ? in view that know-how are actually growing and also getting to often be much more sophisticated. You will discover even now alternative varieties of mass media wherever you can get most of these newspaper and adverts, but even now this Global Multi-level (World-wide-web) is best suited.

This time around free classifieds have become put up on the a number of can i perk the net end users, specifically this users, along with they who require distinct providers. Right now there you will discover job options on the net which usually create your world regarding job-seekers simple as you can. Most of these zero cost classifieds aid a lot inside keeping time period, dollars in addition to attempt in acquiring careers. Around one other way additionally, free area advertising can be useful for creating enterprise relaxed. Internet marketing may be known as when an affordable way of selling services along with other enterprise as that buyers simply are likely to relax as you?re watching laptop, in addition to surf, suitable subsequently and also now there, they could get the services they?ve wanted, thinking that would help make enterprise easier. Publishing free of charge area newspaper in the net is not only just a healthier way with rendering expert services to people but also another way with company, and also earning money on the web. You might be serving other people via your own adverts plus nearby free classified sites, nonetheless, unknowingly, restoring your special company. Help to make free of charge local newspaper that answer to your own trouble as it will be reliable on the subject of building your online business successful.

Are you currently employing as well as considering utilizing cost-free classified web promotion to assist yuor web blog grow? Would you like for you to know how to receive great targeted traffic from categorized promotion? There are some those who are extremely productive having categorized advertisements they usually do very well for themselves. Listed here are the particular advantages and the cons connected with cost-free categorised ads.

The benefits consist of good traffic that is certainly specific and comes routinely. These types of advertising may yank people around 30-40 persons a advert a week rather without difficulty. This is very good contemplating you?ll be able to show up a advert throughout regarding 35 minutes and also therefore. It?s this that can be superb concerning labeled advertising is actually that you can chuck these way up in the urgent. So in the event you live 100 every day you?ll possess a great deal of site visitors arriving to your website.

Most of these adverts are also superb books can create these folks the moment along with publish these to many web sites this allows you to posting your advertising. It is a major profit because doing so is very easy to be able to chuck them upwards all over the web.

This cons connected with categorised classified ads is that these people terminate and also occasionally very quickly. At times you put up advertisements that could reach its expiration date within a few days plus often that they final intended for 1 out of 3 days and nights or even more. The issue is the fact possibly the ones which last pertaining to enough period will certainly tumble up to now affordable your number make will minimize building targeted visitors to suit your needs. This is a huge weakness due to the fact you should change this advertising consistantly.

You?ll be able to help yourself released in a handful of zero cost categorized web marketing and advertising sites reside can pay a smaller fee to obtain a program in addition to quite often it is also possible recreate your current ads to be able to regenerate when they terminate. This can be a large help to you personally plus you should think of this to be a fantastic help.

Article Source: http://www.articlesbase.com/online-promotion-articles/classified-internet-advertising-5818031.html

About the Author

Amit is Writing Online Articles Since Many years and his new website is on Free Classified Ads

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Oakwood Shores Ratchets Up A New Construction Phase ? Curbed ...

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Joomla Web Development and Its characteristics

If talking about Joomla, it is known as the widely known CMS or Content Management System that is actually used for building a website with the most complex and large applications. This is recognized as the most popular open source software system that is easy to use as well as handle. This open source software system can get downloaded easily from the internet and can be used without paying any charges. As you are already aware of the fact that Joomla is a CMS; hence, it can facilitate you towards developing your own website without even having very deep knowledge about the web development and designing. Joomla web development system has become very significant tool in the current era of web development practices due to its quality based as well as catchy features.

Apart from considering its benefits and features, it is quite easy to install Joomla and if its usability is concerned, this system is quite user friendly.

People who are just aware of the simple fundamentals about the computer, they can also create as well as manage their own website with the help of the Joomla CMS. If you wish to make more easy use of Joomla, the online world comprises numerous web design companies that offer the Joomla installation services in a very less time required as well as for making your newly designed website to become ready to run. Joomla comes under the easily accessible CMS and this is the reason why web developers and designers find this system quite easy and comfortable for making their website for the customers that are using Joomla.

There are some of the most significant features of Joomla including the Online Editor (CMS Support), Template Customization Facility, URL Re-writing Support, user-friendly website, management of client contacts, online polls, multiple language support and multiple user access.

There are a wide range of functionalities with Joomla. Either you need to create a simple website or using a complex web application; Joomla facilitates you towards using all kinds of websites. If we are considering the scope for Joomla web development, this system is used for creating the websites of the commercial organizations, educational institutions, profit and non-profit organizations, corporate houses, organizations and industries. There are numerous examples of a Joomla website that can include a personal website, an educational institution?s website, a social website, directory of portals, government portals, corporate portals, community portals and multiple language website.

Nowadays, the popularity of Joomla is rising constantly despite of the emergence of several other CMS, out of which, Wordpress is the most competitive one. The reason behind the growing popularity of the Joomla web development is the support from its online community of Joomla developers from where; the users can acquire all the answers for meeting their queries to the optimum level. This system is quite facilitating and it assures the sure profitability of the website in the web world where a good website drives out more number of customers and encourages the business growth significantly.

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Classic 1937 steam engine soon to run carbon-free

19 hrs.

John Roach

A steam train built in 1937 is getting a makeover that will turn it into a ?higher-speed? locomotive that runs on biocoal, a coal-like fuel made with woody plant material.

When finished, the train will be able chug along existing tracks at speeds up to 130 miles per hour without contributing to the greenhouse gas pollution blamed for global warming.

?Computer simulations already show that the locomotive is about as powerful as two modern passenger diesel locomotives,? Davidson Ward, president of the Coalition for Sustainable Rail, told me Thursday.

?But it will burn carbon neutral fuel.?

The biocoal is based on a so-called torrefaction process pioneered at the University of Minnesota in Duluth. To make it, woody material ? in this case trees ? are heated in the absence of oxygen. The resulting flaky matter is then rammed together under high pressure to create coal-like bricks.

Biocoal has the same energy density as regular coal, but is cleaner burning, and since trees (the fuel source) sequester carbon as they grow, the system is considered carbon neutral, according to Ward.

The heat used to process the fuel comes from biogas, which makes the process 94 to 96 percent thermally efficient, he said.

?So you actually do have something that is as close to carbon neutral as possible,? he noted.

The biocoal will be used to power a 1937 steam locomotive that is being upgraded with a more efficient fire box, boiler and other parts ? though using the same design principles as a traditional steam locomotive.

?It is kind of like the windmill,? Ward said. ?Windmills are very old inventions, but you can modernize it and make it more efficient and apply it today.?

With sufficient funding, the team expects their made-over train to light up the rails sometime in the next two to six years.?

The train will be classified as "higher-speed," which means it can travel on the same rail network as Amtrak and freight trains.?

Rails for high-speed trains, which go 150 to 220 miles per hour, require more specialized tracks.

Today, most higher-speed passenger trains are diesel-electric locomotives, which generate their peak horsepower at low speeds ? about 25 miles per hour. Steam locomotives, by contrast, get their peak horsepower at higher speeds ? about 40 miles per hour.

"Initial computer simulations suggest that the CSR's modern steam engine will significantly out-accelerate a modern diesel-electric locomotive to 110 mph," according to the coalition's website.?

In addition to trains, the steam engine technology can be used to create ?self-contained energy generation units? that could be shipped to the developing world, including the torrifier.

And since these units are based on age-old steam engine technology, they won?t require high-tech skills to perform routine maintenance or fix broken parts.?

The train itself, which Ward?s organization acquired from a museum in Kansas, is considered a proof-principle project. If all goes according to plan, they might build a new steam locomotive from scratch, which will have some modern looks.

For example, ?no cowcatcher,? Ward said. ?You don?t need a cowcatcher today unless you are a 'Back to the Future' fan.?

??Via Clean Technica?

John Roach is a contributing writer for msnbc.com. To learn more about him, check out his website and follow him on Twitter. For more of our Future of Technology series, watch the featured video below.

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Treating pain with transplants

Thursday, May 24, 2012

A new study finds that transplanting embryonic cells into adult mouse spinal cord can alleviate persistent pain. The research, published by Cell Press in the May 24th issue of the journal Neuron, suggests that reduced pain results from successful integration of the embryonic cells into the host spinal cord. The findings open avenues for clinical strategies aimed not just at treating the symptoms of chronic debilitating pain, but correcting the underlying disease pathology.

There are two major classes of chronic pain: inflammatory pain that results from injury to tissue, such as muscle and bone, and neuropathic pain from injury to nerves, for example, in the limbs or face. Damage to nerves can occur after physical trauma and from chemotherapy drugs. With neuropathic pain, the pain occurs in the absence of stimulation, and there is hypersensitivity and exacerbated pain to stimuli that would not normally cause pain. Neuropathic pain is thought to involve the loss of inhibitory neurons that release the chemical GABA, which is an inhibitory neurotransmitter that controls the excitability of neurons, including neurons that transmit pain information.

"Pharmacological approaches to managing neuropathic pain enhance GABA-mediated inhibition. However, some patients do not respond to these therapies and there are significant adverse side effects," explains senior study author, Dr. Allan Basbaum from the University of California, San Francisco. "Therefore, new therapeutic approaches for neuropathic pain are essential." Dr. Basbaum and colleagues explored whether replacement of the damaged inhibitory neurons might be useful for reducing neuropathic pain.

The researchers transplanted immature GABA neurons from mouse fetal brain into the spinal cord of mice with nerve injury-induced pain, a model for human neuropathic pain. The transplanted cells not only survived, but made connections with appropriate targets and integrated into the host spinal cord circuitry. This resulted in an almost complete reversal of the mechanical hypersensitivity generated in a nerve injury model of neuropathic pain. In contrast, the transplant procedure was not effective at reducing pain in a mouse model of inflammatory pain, which is induced by tissue injury.

Taken together, the findings have exciting implications for a cell-based treatment of neuropathic pain in humans. "Our strategy not only ameliorates the symptoms of neuropathic pain but, importantly, is also potentially disease modifying," concludes Dr. Basbaum. "It is worth considering whether transplants such as these might have clinical utility in humans, a great advantage being that the adverse side effects associated with drug administration can be avoided."

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Cell Press: http://www.cellpress.com

Thanks to Cell Press for this article.

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Library of Congress taps 25 sounds for registry

WASHINGTON (AP) ? From rare audio interviews of former slaves to recordings by Donna Summer and the Grateful Dead, 25 sounds that shaped the American cultural landscape are being inducted into the National Recording Registry.

Summer's 1977 hit "I Feel Love" is joining the Grateful Dead's famous 1977 Barton Hall concert as sounds of cultural significance, among 25 additions that are being announced Wednesday by the Library of Congress as part of its registry.

The world's largest library has chosen a diverse array of songs and sounds from history to retain for permanent preservation in the National Recording Registry. Among the new choices this year are Dolly Parton's "Coat of Many Colors," Prince's "Purple Rain" and more.

Some selections are truly historic and rarely heard. They include the only known audio of former American slaves who were interviewed in the 1930s, including one participant who had worked for Confederate President Jefferson Davis. There's also a cylinder from a talking doll created by Thomas Edison in 1888 that is the earliest known commercial sound recording. It was considered unplayable until last year, after new digital mapping tools were used to reveal its sound of a woman singing "Twinkle, Twinkle Little Star."

The library also is saving Leonard Bernstein's conducting debut with the New York Philharmonic in 1943 and "A Charlie Brown Christmas" by the Vince Guaraldi Trio from 1970, which introduced millions of people to jazz through the TV soundtrack.

"America's sound heritage is an important part of the nation's history and culture, and this year's selections reflect the diversity and creativity of the American experience," said Librarian of Congress James Billington, in announcing his final selections.

Though Summer died last week of cancer, her hit single was selected for the sound registry weeks ago, said Matt Barton, the library's curator of recorded sound. Summer had many hits, but "I Feel Love" rose to the top because it was a breakthrough that would change club music for years to come, according to the library's citation.

"From the first time you heard it, it was just, 'Wow, this is very different,'" Barton said. "We hadn't heard this before. It was enormously influential."

The registry includes early sounds from hip-hop with Sugarhill Gang's "Rapper's Delight" from 1979 that is credited with launching a genre and inspiring future artists.

Funk will have its place in the sound history collection with Parliament's "Mothership Connection" from 1975 with George Clinton's "Ain't nothin' but a party, y'all" on the title track.

Blues singer Bo Diddley is being inducted to the sound registry, too, with "Bo Diddley" and "I'm a Man."

For Mickey Hart of the Grateful Dead, Diddley's sound was some of the first beats he learned as a little boy, he told The Associated Press. So he was thrilled that sounds of the Dead were being preserved at the same time.

Hart had a hand in helping create the sound registry, pushing for a law in Congress in 2000. He said he didn't lobby for his own music to be included this year, though he was letting other "lads" in the band know about the honor.

Their music will be represented with the 1977 Barton Hall concert at Cornell University, which has been cited as one of their best performances ever. The recording was hailed for its sound quality.

"The Grateful Dead just touched a nerve, and it's still relevant in many ways today," Hart told the AP. "It's American-based music, but the combination of it, I guess, was the chemical that ignited, the energy that ignited the spirit of the people for many generations."

One key choice they made was to allow fans to record their concerts live, rather than hiring guards to take away recorders. That helped build an army of "Dead heads," Hart said, because they could all take the experience they had paid for with them. And every concert was always different.

Hart said he is impressed with his fellow inductees in the library collection.

"These are not just songs," he said. "These are talking books ? thousands of years of evolutions of cultures are in this music. It represents something even greater, the hopes, the dreams ... the joy, everything it takes to make up a people are embedded in this music."

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Online:

Library of Congress: http://www.loc.gov/

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Follow Brett Zongker on Twitter at https://twitter.com/DCArtBeat .

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