Saturday, April 7, 2012

Hamas executes 3 in Gaza, including "traitor"

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Friday, April 6, 2012

Disarming disease-causing bacteria

ScienceDaily (Apr. 5, 2012) ? New treatments that combat the growing problem of antibiotic resistance by disarming rather than killing bacteria may be on the horizon, according to a new study.

Published in Nature Structure and Molecular Biology, research led by Monash Universityshowed a protein complex called the Translocation and Assembly Module (TAM), formed a type of molecular pump in bacteria. The TAM allows bacteria to shuttle key disease-causing molecules from inside the bacterial cell where they are made, to the outside surface, priming the bacteria for infection.

Lead author and PhD student Joel Selkrig of the Department of Biochemistry and Molecular Biology at Monash said the work paves the way for future studies to design new drugs that inhibit this process.

"The TAM was discovered in many disease-causing bacteria, from micro-organisms that cause whooping cough and meningitis, to hospital-acquired bacteria that are developing resistance to current antibiotics," Mr Selkrig said.

"It is a good antibacterial target because a drug designed to inhibit TAM function would unlikely kill bacteria, but simply deprive them of their molecular weaponry, and in doing so, disable the disease process."

"By allowing bacteria to stay alive after antibiotic treatment, we believe we can also prevent the emergence of antibiotic resistance, which is fast becoming a major problem worldwide."

The Monash team, led by Professor Trevor Lithgow from the Department of Biochemistry and Molecular Biology, showed the TAM was made of two protein parts, TamA and TamB, which function together to form a machine of molecular scale.

Together with colleagues at the University of Melbourne, they compared normal virulent bacteria to mutant strains of bacteria engineered to have no TAM.

"We noticed that proteins important for disease were missing in the outer membrane of the mutant bacteria," Mr Selkrig said.

"The absent proteins help bacteria to adhere to our bodies and perform disease-related functions."

Mr Selkrig said the next step for the group was to dissect the molecular mechanism of how the TAM complex functions and, in collaboration with researchers at the Monash Institute of Pharmaceutical Sciences, design an antibiotic that inhibits the TAM in bacteria.

Professor Lithgow led an international team of seven Monash researchers, and scientists from the University of Melbourne, University of Queensland, the University of Glasgow and University of Birmingham.

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The above story is reprinted from materials provided by Monash University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Joel Selkrig, Khedidja Mosbahi, Chaille T Webb, Matthew J Belousoff, Andrew J Perry, Timothy J Wells, Faye Morris, Denisse L Leyton, Makrina Totsika, Minh-Duy Phan, Nermin Celik, Michelle Kelly, Clare Oates, Elizabeth L Hartland, Roy M Robins-Browne, Sri Harsha Ramarathinam, Anthony W Purcell, Mark A Schembri, Richard A Strugnell, Ian R Henderson, Daniel Walker, Trevor Lithgow. Discovery of an archetypal protein transport system in bacterial outer membranes. Nature Structural & Molecular Biology, 2012; DOI: 10.1038/nsmb.2261

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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#HAchat Recap: Public Health & Health Activism | WEGO Health Blog

Happy National Public Health Week everyone!? In honor of National Public Health week, WEGO Health dedicated this week?s #HAChat to discussing public health issues.? This week serves to recognize the vast strides that have been made in public health in the last century as well as highlight issues that are important to our nation?s health.? This year?s theme is A Healthier America Begins Today: Join the Movement. This week, Health Activists talked about what public health means to them and what public health looks like in their communities.

?

What is public health?

healthyjack a 1920 def. that still works (part 1): ?the science and art of preventing disease, prolonging life and promoting health through organized efforts & informed choices of society, organizations, public and private, communities & individuals? #hachat.

Even while looking at this definition it?s hard to conjure up an exact image of what ?public health? looks like.? It invokes images of PSA?s and food pyramids, workplace fitness programs and smoking bans.? The reason it?s so hard to pinpoint exactly what public health is, is because when public health is working ? you don?t know.? Public health is all around us, it?s everything from clean drinking water and waste removal services, emergency response teams and public restrooms.? It?s the health and safety inspections in restaurants, homes and buildings and the containment of food borne illnesses such as E.coli and Salmonella.? It?s a proactive and preventative approach to keeping the entire population healthy by fighting chronic and infectious diseases, obesity and terrorism.? It?s ensuring that there is equal access to affordable healthcare services. Health Activists were right on in their definitions, and came up with a number of different real life examples of what public health means in our society:

TiffanyAndLupus T1: To me, public health is the promotion of delivering health info, practicing healthy lifestyles, & disease protection/prevention.?#hachat

IIIGifts PH = the things necessary to manage the health and well-being of a population as a whole, not just the individual w/ single encounter?#HAchat

WalkForCure Public health to me means making available resources to stay healthy for everyone, not just those who can afford it.?#HaChat

Dyverse_Steele: to me ph is educating consumers, providing for safe healthy spaces to work and play in i.e. communities #hachat

ConquerLupus: I think of the public health care services. Like urgent care centers and planned parenthood?#HAchat

puffin_77: ?I think of the term in epidemiological terms? population health.?#HAchat

Public health strategies focus on prevention, and they do this by promoting education, awareness and behavior change.? Behavior change, however, takes time.? Hand hygiene, for example.? In the 1800?s, Dr. Semmelweis discovered that there is a lower chance of puerperal sepsis during childbirth if a doctor washes his hands before delivering the baby.? Such a simple intervention has revolutionized not only childbirth, but medicine as a whole.? Yet, to this day, there are still signs in the bathrooms of restaurants instructing workers to wash their hands before returning to work.? This demonstrates that behavior change and awareness are not static concepts, and that ensuring public health requires continual efforts.

?

What does public health look like in your community?

While public health focuses on the health of the population, there are many different ?populations? that make up our society.? As such, public health will vary between regions, towns, socioeconomic groups, gender, and condition.? Here are some examples of what public health looks like in the communities of various Health Activists:

WalkForCure:? Access to healthcare. I live in growing community where a 2hr wait time in a doctor?s office is the norm.?#HAChat

kimmieCollas: access to pain control is a big one, as is doctors who don?t ?believe? in fibro?#HAchat

julianna12369: My local community needs to address issues of the elderly. My?#lupus community needs awareness and research.?#HAchat

eCaring: ?Need for widespread recognition that?#aging of population will require HUGE healthcare system changes #hachat

TiffanyAndLupus: The biggest public health issues that I believe affect the?#lupus community: Lack of disease education about lupus.?The cause & triggers of?#lupus are highly speculated but still unknown, this causes a major issue w/ disease prevention.?#hachat

AnacostiaYogi @wegohealth the biggest health issue in Anacostia is health education! Why have health resources if ppl don?t know about em??#HAchat

Dyverse_Steele for hiv/aids stigma still exists, overall mental health, growing older with hiv, dealing with side effects of medication, jobs?#hachat -3:25 P

LAlupusLady: Public Health issue for#Lupus the racial/sexual disparities need to be understood, which means Research!?#hachat

?

Who is responsible for public health?? What can Health Activists do?

Since public health focuses on the health of entire populations, who is responsible for addressing all of these issues and promoting and maintaining public health?? The answer is that EVERYONE is responsible.? The government has an innate responsibility to ensure access to services, though some people do slip through the cracks.? baljaid:?nowadays not only government is the only responsible for public health, also big companies have social responsibility?#hachat.? Though things are changing slowly, we are starting to see more big companies make investments in local community organizations, clinics and hospitals as well as make strides in protecting the environment, all of which contribute to public health.? Health Activists can also take a role in promoting public health by promoting awareness and education.

TiffanyAndLupus: Health Activists can work together on issues w/public health by using their voice to advocate/& share their views.?#hachat

susanmees: Health Activists are in the unique position to share information with lots of people & that is what public health tries to do.?#hachat

AnacostiaYogi:? Social media, local meetups, supporting each orgs events. Collaboration not competition.#HAchat

TiffanyAndLupus: Health Activists can use tools like social media to share their thoughts on Public Health. Alone we are1, 2gether we?re strong?#hachat

Health Activists are constantly promoting public health by promoting healthier lifestyles for their communities.? In public health, it is often the simplest interventions that have the biggest impact, and harnessing the power of Health Activists to discover what these simple interventions are will be vital for community health programs in the future.

Though your community will always be your best source of support when you?re going through a hard time, banding together across conditions can only benefit you in terms of public health.? People suffering from conditions that cause chronic pain may have different day to day needs, but they also face the same stigma from doctors and healthcare professionals.? Advocating for safer and healthier communities can benefit the health of everyone, no matter your condition.? Health Activists have more in common than not and together can make big strides in improving public health for the entire population.

What does public health mean to you?? What have you done to improve the public health of your community?? Feel free to email us at editorial@wegohealth.com and share your thoughts?

It?s never too late to start participating in the Health Activist Writer?s Month Challenge! There are still 26 more prompts to go! Sign up here: http://info.wegohealth.com/HAWMC2012/ or check our Facebook or Twitter for the day?s prompt as well as posts by other bloggers.? To celebrate Health Activist Writer?s Month, the rest of April?s chats will focus on writing. See you next Tuesday at 3 PM EST.

?

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Thursday, April 5, 2012

Home Staging 101 | autismparentsnetwork.com

The goal of home staging services company would be to make preparing their clients real estate as stress-free an experience as possible. Whether a good occupied property or a empty home staging project, stagers perform as much as they possibly can in order to streamline the procedure so that everything is required of the client is access to the home and a phone call to inform them the task has been finished. Everything in between is actually handled successfully and effectively by the staging organization. One of the results is high-impact home staging project pictures for Multiple listing service and marketing material. Below is really a brief summary of the steps involved in staging a house:

Step 1: The actual Consultation
This is the most important part of the process. The home stager will walk through the property, room by room, and critically assess what must be addressed for every room and space within the home. The majority of home staging companies will then provide the seller wi

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Justin Timberlake, Jessica Biel Planning Big Summer Wedding


Justin Timberlake and Jessica Biel are getting married this summer, and while they have kept a low profile about their engagement, they are going all out.

The couple are pulling out all the stops for a big wedding, reports say.

"Justin and Jessica are planning a big [summer] wedding," a source close to the pair tells People. "Jessica initially wanted a smaller, more intimate wedding, but Justin from the beginning wanted a big wedding and that's what they have decided on."

Justin Timberlake and Jessica Biel in Love

According to the source, Timberlake, 31, and Biel, 30, have decided they want to "include all their friends" in the wedding celebration, says the source.

The pair have recently been spending time together in Atlanta where the burgeoning film star is shooting his latest project, Trouble with the Curve.

Biel, who was seen sporting her engagement ring last month, has yet to decide on her dress, the source notes, but is "very involved" in the planning.

As for the groom-to-be, the source says: "Justin has promised her the best day ever." Can't fault the guy for setting the bar high, can you?

[Photo: WENN.com]

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Sunday, April 1, 2012

Podcast Basics For Camden Point MLM Business Bloggers | Platte ...

Podcast Basics For Camden Point MLM Business Bloggers

Today?s Camden Point direct selling article is for Camden Point internet rookies who want to kick up their web marketing a notch by adding a podcast to their Camden Point home business blog.

A podcast is a multimedia file that is downloaded for playback on a mobile device such as an iPod or laptop computer. It can be a digital recording of a radio program or, more often, a program produced solely for online distribution. A podcast can be a recording of a webcast: a live Camden Point program that is ?streamed? or broadcast on the internet in real time. When this is the case, it is similar to a DVD recording of a live program that you store in the database of your playback device.

A related term is the acronym RSS which probably originally stood for Rich Site Summary feed but is sometimes used for Really Simple Syndication. You have probably seen the term RSS on websites. An RSS feed allows digital files to be downloaded in a standard format. Basehor podcast listeners often subscribe to favorite ongoing podcasts. When new podcasts are produced, they are automatically downloaded by RSS applications.

It is fairly simple hardware- and software-wise to product your own podcast for your Camden Point online business
. Your laptop may already have recording capability. If not, you can buy any equipment you need in the Basehor area.

Camden Point business owners operating on a shoestring will be happy to know that basic recording and editing software can be downloaded for free. If you want to get fancy, you can always buy more sophisticated software at Missouri specialty computer stores. I recommend using a headset microphone so the mic is always in the right spot to get a clear and consistent recording.

Now the fun part: what will you podcast? The possibilities are endless for Camden Point direct marketers. You can record Missouri trade show presentations, interviews with founding distributors of your Camden Point direct sales company, or create an entertaining pitch about your Basehor business opportunity. Let your expertise and enthusiasm shine.

Creating a podcast gives you a chance to connect with potential Camden Point customers or downline members in a personal way.

I am Acai Dark Cacao Connoisseur Adam Paul Green, a network marketer representing Xocai XoBiotic Squares. I am based in Platte Woods, Missouri.

Are you interested in owning a Xocai XoBiotic Squares online business? My team members are steadily expanding their networks and increasing their direct sales income.

Call me today to start building your own online Xocai XoBiotic Squares business!

Acai Dark Cacao Connoisseur Adam Paul Green

Platte Woods, Missouri zip code 64151
801.437.5984 596adampaulgreen@adampaulgreen.com
Xocai XoBiotic Squares residual income opportunity for Camden Point home-based business owners.

Join Winner?s Circle today!

I am Adam Paul Green, and I am a Platte Woods-based Xocai artisan chocolate distributor. I joined Xocai in August 2005. I sell the industry-leading Xocai XoBiotic Squares and X Power Squares online and in Platte Woods, Camden Point, Fort Leavenworth, and Lansing. Our valued Basehor customers recommend X Power Squares because X Power Squares swiss chocolates from Xocai is wonderful!.

Winner?s Circle is also a fantastic Xocai XoBiotic Squares home-based business within 38 miles of the Basehor area. Missouri entrepreneurs can supplement their income by cashing in on a high-demand Missouri healthy artisan chocolate market. To learn more about Winner?s Circle, visit http://adampaulgreen.com/about/.

Call me at 801.437.5984 to own your own Xocai XoBiotic Squares business in Platte Woods, Camden Point, Fort Leavenworth, or Lansing.

The URL for my personal Basehor Xocai chocolate web page in Platte Woods, Missouri 64151 is http://adampaulgreen.com/about/. The URL for another one of my 38 Missouri Xocai artisan chocolate web pages is http://adampaulgreen.com/. I also have a Missouri healthy chocolate page at http://adampaulgreen.com/partnership2/.

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Movie Review: Mirror, Mirror - Centreville, VA Patch

Mirror, Mirror is the first and lighter of two movies based on the tale of Snow White to be released this year. It's a charming, sweet, albeit flawed little confection, worth seeing if you love inventive production and costume design, but especially if you have a soft spot for the work of director Tarsem Singh, who supplies some moments of visual brilliance his fans have come to love.

When a movie lover walks into a film helmed by Singh, they might have certain expectations. This artistic, controversial director is known for visually stunning yet incomprehensible movies like The Fall, The Cell, and most recently, The Immortals. He became famous with the music videos "Hold On" by En Vogue, and "Losing My Religion" for REM, which won Best Video of the Year at the 1991 MTV Awards.

Mirror, Mirror has a cast lead by A-lister Julia Roberts and IT boy Armie Hammer (of The Social Network, J Edgar, and the upcoming The Lone Ranger) and exhibits Singh's unique sensibility, complete with fantastical visual landscapes, with help from his production designer Tom Foden, and Kabuki-esque costuming from longtime collaborator Eiko Ishioka, who passed away in January. His enthusiastic devotees maintain Singh can and will ultimately build a career represented by well-reviewed blockbusters that weave together his trademark visual palette with storytelling that holds together. They are rooting for him to find a vehicle that will make that happen. With Mirror, Mirror, the first film directed by him appropriate for kids, he does get pretty close.

There was much brouhaha about the previews, which displeased Singh and got lots of press. I now see why. I was driven into the theatre by mix of responsibility for my readers and a strong curiosity about what Singh would do with such a mainstream studio film. The previews made it look like a silly retread most moviegoers would give a pass. Actually, although it isn't nearly as funny as I thought it might be, and certainly very goofy in spots, the dialogue is clever, and should appeal to both children and adults with its mix of broad humor and more subtle adult dialogue, which will fly over kids' heads.

While the story is the expected girl power "I rescue myself, thank you" switch up, the characters played by Lilly Collins (Snow White), Armie Hammer (Prince Alcott), and a host of LP (little people) actors (as the seven dwarfs) are more fully developed than in the usual fairy tale fare.

Julia Roberts stars as the Evil Queen. I found her underwhelming, with less bite than I would have liked for someone keeping Snow White and a whole spellbound kingdom under her thumb. Perhaps it was so as not to scare younger viewers, but I found her character and its portrayal far less menacing than, say, Mother Gothel in the Disney cartoon Tangled. She seemed to back away from playing the murderous menace the Queen was supposed to be. I also found the inconsistent English accent Roberts used distracting. Since she's done well with accents before, I have to wonder what acting choice lead her to slip in and out of it so often.

As the villain of the film, she's serviceable, but she doesn't create a lasting impression that will put this role anywhere near her best work. Her costumes, however, are the stuff of dreams. Her gowns are to die for, which may explain why her subjects are starving, as we are told that's where all their tax money is going. Well, Queen, at least it shows in your clothes!

Lilly Collins and Armie Hammer are the real stars here. She charms, he amuses, and together they are a believably smitten duo. Their interactions with the other characters in the film, however, are where they both shine the most.

As you can imagine, if being a person of color means fighting the five great actors getting all the roles, being a little person actor in Hollywood means you must be the very best?and they have indeed brought together the best here, including Mark Povinelli as Half Pint (who has a burning crush on Snow White) Danny Woodburn as Grimm (sort of the Grumpy of his pals) and Jordan Prentice as Napoleon (the leader of the group). They are all memorable actors, each with impressive lists of other movie and TV show credits, and are thoroughly enjoyable here.

The film, clocking in at 1 hour and 35 minutes, moves along swiftly enough, always marked by Singh's unique brand of wild inventiveness, but with varying degrees of success. Some action involving supposedly dangerous life sized puppets juxtaposed with comedic music seems forced and blunted, while the most engaging moments are those with Snow White training and fighting with swords, or scenes with the fantastical environments Singh and his crew create, like the castle and dwarf cottage interiors or the Queen's magical alternate world.

Dark and creepy fairy tales are very in vogue, with Grimm and Once Upon a Time on TV, and the oft compared upcoming Snow White and the Huntsman all bringing the gruesome cautionary aspects of these stories back to the forefront. It's nice to see an alternative version of Snow White that is still watchable and optimistic and won't give little kids nightmares. Sometimes fairy tales can use a little froth. Snow might be a determined young lady on a mission, and may know how to handle a sword, but her gown and crown still take your breath away.

Speaking of costumes, Bjork called. She wants respect back for the time she wore that swan-inspired fashion at the Oscars?It was definitely inspiration for one of Snow's outfits. It's also clear Audrey Hepburn in Roman Holiday was an inspiration for Lilly Collins's styling in general, although her imposing eyebrows are reminiscent of a younger Julia Roberts in Pretty Woman. The metrosexual man inside me wants to mention the gorgeous long coat Armie Hammer wears and whips off during a sword fight. Why don't American men have access to great pieces like this for their wardrobe? (Oh, yeah, 'cause they wouldn't buy them. But I would!)

I urge movie fans looking for family fun at the multiplex for kids 7 and up to consider Mirror, Mirror as a possibility. Is it something you adult couples or pals looking for a great night of hanging out should run to with a passion at your earliest convenience? No. But for families who look for movies that inspire a child's imagination and eye for visual creativity while at the same time giving them something more sophisticated to enjoy, this could be just the ticket. Adult women who love fairy tales and pretty things will also find bits to appreciate here, as will movie lovers curious to see a more mainstream expression of Singh's filmmaking style.

Walking out of the movie, I broke into a discussion about the tiara in Mirror, Mirror with an 8-year-old girl. She didn't bring up the message of girl power or independent thinking, although it might be sinking into her brain somewhere. I figure with all the negatives in this world, there's nothing wrong with appreciating some of the more beautiful, sparkling things. I'm glad Tarsem Singh is the one given a chance to show them to her.

Local showings:

Centreville Multiplex, Friday and Saturday, 9:40 a.m. | 10:50 a.m. | 12:00 p.m. | 1:30 p.m. | 2:40 p.m. | 3:50p.m. | 5:00 p.m. | 6:20 p.m. | 7:20 p.m. | 8:40 p.m.|9:45 p.m. |11:00 p.m.

Additional showtimes on Moviefone.com

Leslie Combemale, "Cinema Siren", is a movie lover and aficionado in Northern Virginia. Alongside Michael Barry, she owns ArtInsights, an animation and film art gallery in Reston Town Center. She has a background in film and art history. She often is invited to present at conventions such as the San Diego Comic Con, where she has been a panelist for The Art of the Hollywood Movie Poster and the Harry Potter Fandom discussion. See more of her reviews and interviews on www.artinsightsmagazine.com.

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